Anthracite coal briquette gas is complex, which is made of CO, SO2, NO2 and H2S. Each of them has been known to make a its own characteristic pathologic change. Therefore, various pathologic changes have been reported in the Anthractive coal
briquette
gas poisoning.
Particularly, Acute renal failure in the CO poisoning has been one of main topics to many clinicians.
Some reserchers presented tissue hypoxia in the early stage of renal damage and rhabdomyolysis in the following stages for the etiological aspects.
However, the exact cause of the damage is not yet well characterized.
We exposed 44 house rabbits with anthractite coal briquette gas & glycerol under the acute condition as well as the chronic condition, and we observed patologic changes sequentially in the course of time, so that we tried to elucidate the extent
of
damage effects of the rhabdomyolysis by morphologically comparing the renal pathologic changes of rabbits caused by anthracite coal briquette gas poisoning with that by rhabdomyolysis.
The rhabddomyolysis was induced by injection of 50% glycerol intramuscullary.
@ES The obtained results were as follows.
@EN 1) The glolmerulus was relatively well preserved, but the tubular and interstitial change, as congestion, vascular dilatation, edema were severe, and dependent on doses, under the acute exposure of anthracite coal briquete gas and glycerol in
both.
2) The more severe damages of the kidney was noted in the chronic exposure of anthracite coal briquette gas as compare in the acute exposure, but the recovering change was found in the chronic exposure of glycerol.
3) The severe congestion, edema were observed in either of coal gas exposure and glycerol, but the inflammatory change with the mononuclear fell infiltration was confirmed in the acute exposure of coal gas, as well as in the chronic exposure of
glycerol.
4) The patholotgic findings of renal injury after exposure of anthracite coal briquette gas and glycerol were different.
And so, the rhabdomyolysis was not considered be the main cause of renal damage, even though it could be the concomitant factor of renal injury .
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